Hemoglobin is a large protein molecule that consists of four subunits (2 alpha chains and 2 beta chains). Hemoglobin is synthesized within red blood cells and functions to reversibly bind oxygen molecules. The alpha and beta chains are products of two separate genes found on different chromosomes. Individuals that have sickle cell anemia have two copies of a "mutated" form of the gene that encodes for the beta subunit. This form differs from the original in only 1 nucleotide. The protein encoded by the normal gene is designated HbA while the protein found in individuals with sickle cell anemia is HbS. Below is a portion of the nucleotide sequence found in the template DNA for the beta subunit of HbA. The start codon is not shown. Assume the reading frame begins at the left.
3' C A C G T G G A C T G A G G A C T C C T C 5'
In HbS, adenine is substituted for the thymine underlined in the sequence above. How does the mRNA in HbS differ from the mRNA in HbA?
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